Formulation and Evaluation of Emulgel of an Antifungal Drug for Topical Drug Delivery

The study developed and evaluated an emulgel for topical delivery of the antifungal drug fluconazole, using jojoba oil and liquid paraffin as carriers. Through a Central Composite Design, 14 formulations were tested, with formulations F1, F8, F7, and F14 achieving over 80% drug release within 3 hours. The study found that lower amounts of jojoba oil and liquid paraffin increased spreadability, while higher viscosity slowed drug release. The optimal formulation included 11.5% oil phase and 1.75% gelling agent, resulting in efficient drug release and improved spreadability. The emulgel showed potential as a topical delivery system, offering benefits like improved bioavailability, reduced side effects, and better stability compared to conventional oral forms.