Hair Transplantation in Mice: Challenges and Solutions

April 2016 in “ Wound Repair and Regeneration ”

Azar Asgari, Nicholas W Rufaut, Wayne A. Morrison, Rodney J. Dilley, Russle Knudsen, Leslie Jones, Rodney Sinclair

hair follicle transplantation GFP transgenic mice nude mice whisker follicles back skin innervation circulatory system healing epithelium wounded skin interfollicular epidermis skin homeostasis

Studysummary In this study, researchers developed a new murine model for transplanting vibrissae that mimics human hair transplantation, achieving successful hair growth in immune-deficient nude mice.

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Single Follicular Unit Transplantation Reconstructs Arrector Pili Muscle and Nerve Connections and Restores Functional Hair Follicle Piloerection

research Single Follicular Unit Transplantation Reconstructs Arrector Pili Muscle and Nerve Connections and Restores Functional Hair Follicle Piloerection

13 citations , March 2012 in “The Journal of Dermatology”

This study reports that transplanted mouse hair follicles restored piloerection ability and connected properly with host tissues, suggesting potential for advanced hair restoration therapies.

research Hair Morphogenesis In Vitro: Formation of Hair Structures Suitable for Implantation

43 citations , August 2008 in “Regenerative Medicine”

In this study, murine follicular cell aggregates developed into hair-like structures in culture, which upon implantation into mice skin matured into complete hair follicles, suggesting potential for treating hair loss.

research Prolactin Delays Hair Regrowth in Mice

53 citations , November 2006 in “Journal of Endocrinology”

This study found that prolactin plays a direct role in regulating the timing of hair growth cycles in mice by affecting the skin, rather than through other endocrine factors.

research Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis

1279 citations , November 2005 in “Nature Medicine”

research Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons

419 citations , March 2005 in “Proceedings of the National Academy of Sciences”

This study demonstrated that ND-GFP stem cells from the hair-follicle bulge area can differentiate into various cell types, including neurons, suggesting their potential as a source for therapeutic applications.

research Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells

212 citations , August 2004 in “Proceedings of the National Academy of Sciences”

This study found that nestin-driven GFP labels blood vessels originating from hair follicles in mice, which could be used to study early events in skin angiogenesis and for antiangiogenesis drug screening.

research Follicular Transplantation

72 citations , September 1997 in “Dermatologic Surgery”

This review discusses follicular transplantation for hair restoration, highlighting the importance of evaluating patient suitability and careful planning to achieve excellent cosmetic outcomes, but reports no new research findings.

research Human Hair Follicle Regeneration Following Amputation and Grafting into the Nude Mouse

72 citations , December 1996 in “Journal of Investigative Dermatology”

This study observed that human hair follicles were able to regenerate fiber-forming structures after the bulb was amputated and transplanted onto athymic mice, suggesting a general regenerative capacity.

research Elliptical Donor Stereoscopically Assisted Micrografting as an Approach to Further Refinement in Hair Transplantation

172 citations , December 1994 in “The Journal of Dermatologic Surgery and Oncology”

This study introduces a hair transplantation method combining elliptical excision and micrografting, suggesting it provides significant cosmetic improvements for androgenetic alopecia.