Effects of Keratin-Gelatin and Basic Fibroblast Growth Factor-Gelatin Composite Film on Open Wound Healing in Dogs and Cats

The study investigated the effects of keratin-gelatin and basic fibroblast growth factor (bFGF)-gelatin composite films on wound healing in dogs and cats. Conducted on 36 dogs, the research found that keratin-gelatin composite films significantly improved wound healing, showing higher rates of epithelialization, wound contraction, and total healing compared to bFGF-gelatin films. The keratin-gelatin film also facilitated early vascularization and acceptance of full-thickness skin mesh grafts, with 90-100% acceptance by Day 20. The study concluded that keratin-gelatin composite films were effective wound healing stimulants, offering a cost-effective treatment option for extensive wounds in animals. Further research was suggested to explore different concentrations of these biomaterials.