Advantages of Incomplete Digestion in Human Hair Shaft Proteomics: A Focus on Cuticular Keratins

This study found that the PLEE method increased hair protein extraction efficiency threefold and that bleaching hair reduced the coverage of keratin and associated proteins, leading to poorer hair quality, though it did not affect the overall protein identification.

This study found that optimizing proteomic genotyping conditions from single human hair samples significantly improves the detection of genetically variant peptides, enhancing human identification with high precision across different biogeographic backgrounds.

This study found that genetically variant peptides from human hair can reliably identify individuals despite differences in age and storage conditions, provided environmental and processing factors are controlled.

This study found that hair proteome profiling and genetically variant peptide identification in hairs remained effective after an explosive blast, indicating potential for forensic human identification despite damage.

This study found statistically significant patterns in hair morphology and ultrastructure linked to biogeographic ancestry among European, African, and East Asian populations.

This study developed a method for extracting proteins from micro-sized human head hairs, facilitating proteomic analysis even with limited hair sample availability.

This study found that while molecular hair structures were nearly identical across individuals, genetic factors seem to influence specific lipid compositions, as seen in identical-patterned hair from parent-child pairs and identical twins, but not fraternal twins.

This study found that beard hair medulla cells express an unexpected range of keratins, showing variability and promiscuous behavior in keratin interactions distinct from other hair follicle cells.

This review summarizes fundamental concepts and recent advancements in hair follicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.

Asian hair is stronger and more damage-resistant than Caucasian hair due to a thicker cuticle layer.

This study establishes a catalog of human type I hair keratins and identifies their specific roles and expression patterns during hair differentiation and growth in scalp follicles.

This article reviews the molecular characteristics of human hair keratins, noting their distinct classification from epidermal keratins and the variability in expression that may occur without noticeable hair changes, but reports no new study results.