Immunoguided Cutaneous Regeneration: A Theoretical Framework Linking Extracellular Matrix, Immunity, and Skin Allografts

August 2026 in “ Frontiers in Immunology ”

Marcelo Fonseca

extracellular matrix skin allografts alloimmune response cutaneous regeneration dermal extracellular matrix immune activation cellular colonization epidermal elimination regenerative remodeling skin allotransplantation

Studysummary This study introduces Immunoguided Cutaneous Regeneration as a potential framework for understanding skin allotransplantation, suggesting that regeneration may depend on the preserved extracellular matrix and a regulated immune response.

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