Natural Compound Isoliensinine Inhibits Stress-Induced Hair Greying by Blocking Beta-2-Adrenoceptor

The document reports on a study that identifies the natural compound isoliensinine as an effective inhibitor of stress-induced hair greying. It explains that stress can cause the release of norepinephrine, which activates β-2 adrenergic receptors on melanocyte stem cells (MeSCs) in hair follicles, leading to the rapid loss of these cells and subsequent hair greying. Isoliensinine, found through screening the ZINC 15 compound database, was shown to prevent this process in mice, suggesting potential for the development of natural products to combat stress-related hair greying.