Natural Compound Isoliensinine Inhibits Stress-Induced Hair Greying by Blocking Beta-2-Adrenoceptor

The study explores isoliensinine, a natural compound from lotus plumule, as an inhibitor of stress-induced hair greying by blocking the β2-adrenoceptor. Computer-aided drug design showed isoliensinine's strong binding affinity to the β2-adrenoceptor, similar to propranolol. In vitro tests with human melanoma cells confirmed its effectiveness in blocking noradrenaline-induced signaling. An animal study with 10 mice per condition revealed that topical isoliensinine significantly reduced stress-induced grey hair from 29.2% to 9.6%, comparable to propranolol. These results suggest isoliensinine as a promising agent for preventing stress-induced hair greying.