TLDR Guidelines help design better trials to compare alopecia areata treatments.
The document discussed the challenges in comparing the efficacy of various treatments for alopecia areata due to the lack of consideration for spontaneous regrowth, baseline prognostic factors, and quantification of hair growth in case reports and clinical trials. It provided guidelines for clinical trial design that accounted for variables like baseline severity, pattern, duration of hair loss, age, and concomitant conditions. The report also covered reliable methods for assessing efficacy and response criteria to enable direct comparison of results between different treatments.
Cited in this study
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44 citations
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October 2009 in “Journal of the American Academy of Dermatology” Topical bexarotene 1% gel might help regrow hair in alopecia areata and is generally safe.
164 citations
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April 2008 in “Cochrane library” Current treatments for alopecia show no significant long-term benefits.
16 citations
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August 2003 in “Journal of The American Academy of Dermatology” Nitrogen mustard was not very effective for hair regrowth in alopecia areata and has potential skin cancer risk.
146 citations
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July 2003 in “Journal of the American Academy of Dermatology” Clobetasol propionate ointment can help some people with total hair loss regrow hair.
34 citations
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January 1987 in “Dermatology” Topical minoxidil effectively and safely treats extensive alopecia areata but doesn't change its course.
148 citations
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March 2019 in “Journal of autoimmunity” Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.
4 citations
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November 2018 in “JAAD case reports” Alopecia areata can sometimes appear as a straight line of hair loss instead of round patches.
May 2018 in “Journal of cosmetology & trichology” Combining platelet-rich plasma therapy with prostaglandin-F eye drops can significantly regrow hair in alopecia universalis.
110 citations
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December 2013 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Alopecia areata is a genetic and immune-related hair loss condition that is often associated with other autoimmune diseases and does not typically cause permanent damage to hair follicles.