Influence of Human Placenta Extracts on Prostanoids Production in Cultured Hair Follicle-Derived Keratinocytes: The Possibility of Pharmaceutical Regenerative Medicine

    January 2020 in “ Journal of St. Marianna University ”
    Fumito Sugaya, Rena Sumie, Ryota Nabeshima, Ryotaro Miyano, Takayuki Takeuchi, Nagaoki Wakisaka, Kazuhiro Kobayashi, Hajime Inoue, Akiyoshi Kajikawa
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    TLDR Human placenta extract may promote hair growth by affecting certain lipid compounds.
    The study from 2019 investigated the effects of human placenta extract (HPE) on hair loss, specifically its impact on arachidonic acid metabolism in cultured hair follicle-derived keratinocytes. The research found that HPE enhanced the production of prostanoids PG-E2 and PG-F2a, which are associated with hair growth, while it decreased the production of PG-D2, which is linked to hair loss. The study also found that HPE significantly increased the PG-E2/PG-D2 and PG-F2a/PGD2 ratios, suggesting that the effects of HPE on hair growth could be mediated by its effects on arachidonic acid metabolism. In contrast, the hair growth medication minoxidil showed no significant effect on arachidonic acid metabolism.
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