Influence of Human Placenta Extracts on Prostanoids Production in Cultured Hair Follicle-Derived Keratinocytes: The Possibility of Pharmaceutical Regenerative Medicine

    January 2020 in “ Journal of St. Marianna University ”
    Fumito Sugaya, Rena Sumie, Ryota Nabeshima, Ryotaro Miyano, Takayuki Takeuchi, Nagaoki Wakisaka, Kazuhiro Kobayashi, Hajime Inoue, Akiyoshi Kajikawa
    Image of study
    TLDR Human placenta extract may promote hair growth by affecting certain lipid compounds.
    The study from 2019 investigated the effects of human placenta extract (HPE) on hair loss, specifically its impact on arachidonic acid metabolism in cultured hair follicle-derived keratinocytes. The research found that HPE enhanced the production of prostanoids PG-E2 and PG-F2a, which are associated with hair growth, while it decreased the production of PG-D2, which is linked to hair loss. The study also found that HPE significantly increased the PG-E2/PG-D2 and PG-F2a/PGD2 ratios, suggesting that the effects of HPE on hair growth could be mediated by its effects on arachidonic acid metabolism. In contrast, the hair growth medication minoxidil showed no significant effect on arachidonic acid metabolism.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 830 results

      community Which mesotherapy should I choose?

      in Research/Science  1 upvotes 6 months ago
      A user is considering adding PRP and mesotherapy to their hair loss treatment and is deciding between two options: Promoitalia, which contains Phosphatidic acid, Riboflavin, and Superoxide dismutase, and the more expensive Melsmon, a human placenta derivative. They seek advice on which option to choose based on effectiveness and scientific backing.

      community This guy claims stem cells fixed his balding

      in Is this regrowth?  301 upvotes 1 year ago
      A man who claimed to have regrown his hair using stem cell treatment, sparking a debate about its effectiveness and cost. Some users suggested he might be using other treatments or substances, while others shared their own experiences with stem cell therapy for hair loss.

      community Verteporfin day 119 update - donor hair regeneration human trial

      in Research/Science  146 upvotes 2 years ago
      A human trial of verteporfin, a drug that can inhibit wound healing by scarring and promote regeneration of original tissue and hair follicles to provide an unlimited source for hair transplants; people discussed the potential of this drug and how it could be rolled out in mainstream with more doctors getting on board.

    Related Research

    1 / 1 results