Increase in IL-15 levels in patients with alopecia areata

September 2020 in “ Journal of Education Health and Sport ”

Dominika Madras, Agata Rocka, Faustyna Piędel, Dominika Psiuk, Emilia Nowak

Interleukin-15 alopecia areata autoimmune condition hair loss IL-15 mouse models AA

TLDR Higher IL-15 levels are linked to more severe hair loss in alopecia areata.

The study reviewed the role of Interleukin-15 (IL-15) in alopecia areata (AA), an autoimmune condition causing hair loss. It found that IL-15 levels were significantly higher in AA patients compared to controls and increased with the severity of hair loss. In mouse models, blocking IL-15 and related pathways prevented disease progression. Despite these findings, the study concluded that there were insufficient studies to determine the therapeutic potential of targeting IL-15 in treating AA.

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Increase in IL-15 levels in patients with alopecia areata

Research cited in this study

research The Effect of JAK Inhibitor on Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells

research Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study

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research Treatment of Alopecia Areata: An Australian Expert Consensus Statement

research UVA-1 in the Treatment of Alopecia Areata

research Alopecia Areata: A Comprehensive Review of Pathogenesis and Management

research Psychocutaneous Diseases: A Review of Psychiatric Disorders with Skin Manifestations and Their Prevalence in Dermatological Settings

research JAK Inhibitors in Dermatology: The Promise of a New Drug Class

research Biomarkers of Alopecia Areata Disease Activity and Response to Corticosteroid Treatment

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

research Alopecia Areata: Clinical Presentation, Diagnosis, and Unusual Cases

research Alopecia Areata: Clinical Presentation, Diagnosis, and Unusual Cases

research Genomewide Scan for Linkage Reveals Evidence of Several Susceptibility Loci for Alopecia Areata

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