TLDR Two impurities in finasteride were identified and characterized as cyclohexyl and phenyl analogs.
The document assessed the impurity profile of finasteride, focusing on potential carry-over impurities from reagents used in its synthesis. Impurities in the reaction mass were monitored using HPLC, and potential impurities were isolated with preparative HPLC. Their structures were confirmed through 1H NMR, MS, and MS-MS. The study identified and characterized two impurities as cyclohexyl and phenyl analogs of finasteride, providing insights into the synthesis process and impurity control.
November 2020 in “Journal of The American Academy of Dermatology” Finasteride 1 mg every other month works as well as daily dose for hair loss maintenance.
June 2019 in “Journal of Drug Delivery and Therapeutics” Finasteride effectively treats hair loss and prostate issues with minimal side effects.
January 2013 in “China Medical Abstract of Dermatology” Finasteride effectively reduces acne with minimal side effects.
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October 2004 in “PubMed” Finasteride, especially in a 1mg dose, effectively slows hair loss and improves hair growth in Japanese men with male pattern hair loss.
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June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Finasteride effectively improves hair growth and slows hair loss in men with male pattern baldness.
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June 2001 in “PubMed” Finasteride is effective in growing hair and stopping hair loss in men with mild to moderate alopecia.
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October 1995 in “International Journal of Dermatology” Finasteride helps treat skin issues like acne and baldness by blocking testosterone conversion.
