Study of the Impact of SKPs' Secreted Factors and a Botanical Extract Derived from Jasmine on Keratinocyte Growth and Reconstructed Human Epidermis Thickness

In 2016, a study was conducted to investigate the impact of skin-derived precursors (SKPs) and a botanical extract from jasmine on keratinocyte growth and the thickness of reconstructed human epidermis (RHE). The study found that the botanical extract positively influenced the growth of keratinocytes in vitro. When fibroblasts and SKPs were treated with 1% of the botanical extract, the thickness of RHE significantly increased in the presence of secreted factors from untreated fibroblasts, but remained unchanged when fibroblasts were treated with the extract. However, treating SKPs with the extract resulted in a cumulative effect on RHE thickness. The morphology of the RHE cultivated with SKPs factors displayed a honeycomb pattern similar to healthy skin, unlike when using the RHE medium. The study concluded that SKPs factors impact keratinocytes and RHE, with a more pronounced effect when SKPs were pre-treated with the botanical extract.