IKZF1 and Ikaros Overexpression Results in Alopecia Areata-Like Phenotype in Mice

    March 2025 in “ Experimental Dermatology ”
    Yukiyasu Arakawa, Risa Tamagawa‐Mineoka, Mayumi Ueta … Norito Katoh
    Studysummary This study found that transgenic mice overexpressing IKZF1 developed lesions similar to alopecia areata, suggesting that Ikaros may play a role in the disease's pathogenesis. Ikaros expression was also higher in human alopecia areata patients compared to controls.
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    Research cited in this study 10

    1. Dissociated Skin Cells Regenerate Hair Follicles in a Microwound: The Punch Assay Experimental Dermatology · 2018
    2. CXCR3 Blockade Inhibits T Cell Migration Into the Skin and Prevents Development of Alopecia Areata Journal of Immunology · 2016
    3. Polymorphisms in the Promoter Regions of the CXCL1 and CXCL2 Genes Contribute to Increased Risk of Alopecia Areata in the Korean Population Genetics and Molecular Research · 2015
    4. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    5. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    6. Topical and Intralesional Therapies for Alopecia Areata Dermatologic therapy · 2011
    7. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    8. Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle Autoimmunity Reviews · 2005
    9. Alopecia Areata in C3H/HeJ Mice Involves Leukocyte-Mediated Root Sheath Disruption in Advance of Overt Hair Loss Veterinary pathology · 2003
    10. Alopecia Areata in Aging C3H/HeJ Mice Journal of Investigative Dermatology · 1994

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