Hyperprogesteronism Due to Bilateral Adrenal Cortex Carcinomas in a Cat with Diabetes Mellitus

An 8-year-old male castrated Russian Blue cat exhibited symptoms such as polyuria, polydipsia, polyphagia, abdominal enlargement, unkempt hair, and abdominal alopecia. Initially diagnosed with diabetes mellitus, further investigation revealed severe bilateral enlargement of the adrenal glands. Despite suspicions of hypercortisolism, cortisol levels were undetectable, while high progesterone levels were found. Histological analysis identified the adrenal masses as bilateral adrenal cortex carcinomas. This case demonstrated that adrenal gland tumors could secrete sex hormones like progesterone instead of cortisol, with clinical signs of hyperprogesteronism mirroring those of hypercortisolism.