Effects of Hyperbaric Oxygen Therapy on Rat Facial Skin

March 2015 in “ Human & Experimental Toxicology ”

Bilal Sula, Cenap Ekinci, Haydar Uçak, Derya Uçmak, ZM Akkurt, Ayfer Aktaş, M Arica, Engin Deveci

hyperbaric oxygen therapy epidermal hyperplasia basal-cell hypertrophy subepithelial fibrosis E-cadherin vimentin type IV collagen connective tissue mononuclear cell infiltration HBO therapy

TLDR Hyperbaric oxygen therapy significantly altered rat facial skin structure.

The study on hyperbaric oxygen (HBO) therapy in 12 rats revealed that HBO treatment caused significant pathological changes in facial skin, such as epidermal hyperplasia, degeneration, and subepithelial fibrosis. There was a reduction in E-cadherin expression, indicating impaired cell adhesion, and increased vimentin and type IV collagen expression in the dermis. Additionally, increased connective tissue, hemorrhage, and mononuclear cell infiltration were observed. These results suggested that HBO therapy could adversely affect skin structure, highlighting the need for further research to understand these effects.

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Effects of Hyperbaric Oxygen Therapy on Rat Facial Skin

Research cited in this study

research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues II: Concomitant and Mutually Exclusive Synthesis of Trichocytic and Epithelial Cytokeratins in Diverse Human and Bovine Tissues (Hair Follicle, Nail Bed and Matrix, Lingual Papilla, Thymic Reticulum)

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