Effects of Hyperbaric Oxygen Therapy on Rat Facial Skin

March 2015 in “ Human & Experimental Toxicology ”

Bilal Sula, Cenap Ekinci, Haydar Uçak, Derya Uçmak, ZM Akkurt, Ayfer Aktaş, M Arica, Engin Deveci

hyperbaric oxygen therapy epidermal hyperplasia basal-cell hypertrophy subepithelial fibrosis E-cadherin vimentin type IV collagen connective tissue mononuclear cell infiltration HBO therapy

Studysummary This study found that hyperbaric oxygen treatment in rats led to structural changes in epidermis and dermis, including decreased E-cadherin expression and increased connective tissue.

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The study on hyperbaric oxygen (HBO) therapy in 12 rats revealed that HBO treatment caused significant pathological changes in facial skin, such as epidermal hyperplasia, degeneration, and subepithelial fibrosis. There was a reduction in E-cadherin expression, indicating impaired cell adhesion, and increased vimentin and type IV collagen expression in the dermis. Additionally, increased connective tissue, hemorrhage, and mononuclear cell infiltration were observed. These results suggested that HBO therapy could adversely affect skin structure, highlighting the need for further research to understand these effects.

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research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues II: Concomitant and Mutually Exclusive Synthesis of Trichocytic and Epithelial Cytokeratins in Diverse Human and Bovine Tissues (Hair Follicle, Nail Bed and Matrix, Lingual Papilla, Thymic Reticulum)

187 citations , May 1988 in “Differentiation”

This study found that trichocytic cytokeratins, typically found in hair, are also present in nails, filiform papillae of the tongue, and the epithelial reticulum of the thymus.