Effects of Hyperbaric Oxygen Therapy on Rat Facial Skin

March 2015 in “ Human & Experimental Toxicology ”

Bilal Sula, Cenap Ekinci, Haydar Uçak, Derya Uçmak, ZM Akkurt, Ayfer Aktaş, M Arica, Engin Deveci

hyperbaric oxygen therapy epidermal hyperplasia basal-cell hypertrophy subepithelial fibrosis E-cadherin vimentin type IV collagen connective tissue mononuclear cell infiltration HBO therapy

TLDR Hyperbaric oxygen therapy significantly altered rat facial skin structure.

The study investigated the effects of hyperbaric oxygen (HBO) therapy on the facial skin of rats, revealing several histopathological changes. In the HBO-treated group (n = 6), there was evidence of epidermal hyperplasia and degeneration, basal-cell hypertrophy, and subepithelial fibrosis. The treatment led to reduced E-cadherin expression, indicating potential impairment of intracellular adhesion. Additionally, there was increased vimentin immunoreactivity and type IV collagen expression in the dermis, along with increased connective tissue, hemorrhage, and mononuclear cell infiltration. These findings suggested that HBO therapy significantly affected both the epidermal and dermal structures in rats.

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Effects of Hyperbaric Oxygen Therapy on Rat Facial Skin

Research cited in this study

research Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues II. Concomitant and mutually exclusive synthesis of trichocytic and epithelial cytokeratins in diverse human and bovine tissues (hair follicle, nail bed and matrix, lingual papilla, thymic reticulum)

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