Development of Hyperalgesia in Patients with Androgenetic Alopecia Treated with Autologous PRP

April 2018 in “ Selçuk Üniversitesi Tıp Fakültesi dergisi ”

Mehmet Yildirim, Bilsev Ince, Orkun Uyanik, Mehmet İhsan Okur, Mehmet Dadaci

androgenetic alopecia platelet-rich plasma PRP hyperalgesia growth factors hair density androgenic alopecia

TLDR Repeated PRP injections for hair loss can cause increased pain sensitivity.

The study investigated the development of hyperalgesia in patients with androgenetic alopecia treated with autologous platelet-rich plasma (PRP). Ten male patients aged 25-35 received PRP injections in the scalp over a year, experiencing increased pain sensitivity after each application, with the highest hyperalgesia observed in the first year post-treatment (p < 0.05). Hair density increased by 6.4%, 9.4%, 21%, and 27.6% at 1, 2, 6, and 12 months, respectively. The study concluded that repeated PRP injections could cause hyperalgesia, potentially due to growth factors in PRP, and recommended further research to understand this phenomenon.

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