Development and Validation of HPLC Method for Simultaneous Estimation of Minoxidil and Finasteride in Topical Solution

    December 2023 in “ International Journal of Advanced Research in Science, Communication and Technology ”
    S. S. Deshmukh, Anamika N Kale
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    TLDR A reliable method was created to measure Minoxidil and Finasteride in a solution.
    A validated HPLC method was developed for the simultaneous estimation of Minoxidil and Finasteride in a topical solution. Using an ODS C18 column and a mobile phase of Buffer (pH 7.0) and ACN (80:20% v/v), the method achieved precise separation with retention times of 2.967 min for Finasteride and 5.750 min for Minoxidil. The calibration curves were linear for Minoxidil (20-80 µg/ml) and Finasteride (0.5-1.6 µg/ml). The method was successfully applied to pharmaceutical formulations without interference from excipients, making it suitable for routine quality control.
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