Evaluation of Some Hormones, Total Antioxidant Capacity, and Malondialdehyde Levels in Polycystic Ovarian Syndrome Women Attending the Gynecology Clinic at Nnewi

    May 2024 in “ Journal of drug delivery and therapeutics ”
    Patrick O. Manafa, Charles Chinedum Onyenekwe, Nkiruka Nwamaka Eze, Sumathi Narayana, N. Osakue, Joseph Chimezie Awalu, Tochukwu Anthony Ikwelle
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    TLDR Women with PCOS have higher oxidative stress and hormone imbalances, suggesting managing oxidative stress could help.
    This study investigated oxidative stress and hormone imbalances in 45 women with polycystic ovarian syndrome (PCOS) compared to 45 controls. Results showed significantly higher levels of DHEA, LH, FSH, and testosterone in the PCOS group, along with increased malondialdehyde (MDA) levels, indicating higher oxidative stress. No significant differences were found in estradiol and progesterone levels or total antioxidant capacity (TAC) between the groups. The study concluded that oxidative stress and hormone imbalances are prevalent in women with PCOS, suggesting that managing oxidative stress could be a potential therapeutic approach for the condition.
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