Hair Follicle Associated Pluripotent (HAP) Stem Cells from Young Mice Have the Greatest Potential to Differentiate to Cardiac Muscle Cells

April 2017 in “ Journal of dermatological science ”

Aiko Yamazaki, Yuko Hamada, Nobuko Arakawa, Masateru Yashiro, Sumiyuki Mii, Ryoichi Aki, Katsumasa Kawahara, Robert M. Hoffman, Yasuyuki Amoh

hair follicle pluripotent stem cells HAP stem cells differentiation cardiac muscle cells regenerative medicine stem cells heart cells regenerative therapy

Studysummary This study found that the ability of hair-follicle-associated pluripotent stem cells to differentiate into cardiac muscle cells decreased sharply with age in mice, suggesting early stem cell banking for future regenerative treatments.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

View this study on jdsjournal.com →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations , January 2001 in “Cell”

This study demonstrated that multipotent stem cells in adult mice whisker follicles migrate to produce whisker growth, and that this process requires precise control of stem cell trafficking.

research Early-age-dependent selective decrease of differentiation potential of hair-follicle-associated pluripotent (HAP) stem cells to beating cardiac-muscle cells

6 citations , July 2016 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)”

This study observed that HAP stem cells from the whiskers of young mice near the ear differentiated into heart-muscle cells more efficiently than those from older mice or other whisker locations.

research Poly-D,L-Lactic Acid Filler Increases Hair Growth by Modulating Hair Follicular Stem Cells in Aged Skin

December 2025 in “Cells”

In this study, PDLLA treatment in middle-aged mice was observed to enhance hair growth by increasing macrophage M2 polarization and hair follicle stem cell proliferation, potentially rejuvenating the skin's microenvironment and offering a novel approach for age-related hair loss.

research Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications

232 citations , October 2015 in “International journal of molecular sciences”

This review discusses the role of epidermal and other adult stem cells in skin repair, focusing on their potential therapeutic applications for non-healing wounds and other skin disorders, but reports no new research results.

research Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment

11 citations , March 2016 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)”

This study found that young host mice rejuvenated aged hair follicles after transplantation, while aged host mice did not support hair growth from transplanted follicles.