Hair Regrowth in a Patient with Alopecia Universalis and Psoriasis Vulgaris Under Deucravacitinib Therapy

    February 2025 in “ JDDG Journal der Deutschen Dermatologischen Gesellschaft ”
    C. Jonas, Michael P. Schön, Rotraut Mößner
    TLDR Deucravacitinib helped a man regrow hair and improve psoriasis.
    A 51-year-old man with alopecia universalis (AU) and psoriasis vulgaris experienced significant hair regrowth after treatment with Deucravacitinib, a TYK2 inhibitor. Despite previous ineffective topical treatments, the patient's hair, including eyebrows and scalp hair, began to regrow within 6 weeks of starting Deucravacitinib, with substantial improvement observed over 7 months. The patient's Psoriasis Area and Severity Index (PASI) improved from 8 to 4, and the Severity of Alopecia Tool Score (SALT-Score) decreased from 97 to 13. The Dermatology Life Quality Index (DLQI) also improved significantly. No adverse events were reported. This case suggests Deucravacitinib may be effective for AU, warranting further controlled studies.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Average r/bald user complaining

      in Satire  398 upvotes 3 months ago
      Hair loss treatments like Minoxidil, finasteride, and RU58841, focusing on their effectiveness and side effects. It also highlights the disparity in medical research funding between hair loss and conditions like endometriosis.

      community Sunlight: Does it Stimulate Hair Growth or Hair Loss?

      in Research/Science  64 upvotes 1 year ago
      The conversation discusses whether sunlight exposure affects hair growth or loss, with mixed anecdotes and theories but no clear consensus. Some suggest moderate sunlight can benefit hair by providing vitamin D, while others doubt its effectiveness compared to treatments like Minoxidil or finasteride.
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      by MagicBold in Research  865 upvotes 1 year ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community C’est terrible - at my wits end

      in Female  450 upvotes 2 years ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

    Related Research

    7 / 7 results