Treatment of Hair Loss in the Trichorhinophalangeal Syndrome

    January 2018 in “ Annals of dermatology/Annals of Dermatology ”
    Mi Soo Choi, Myeongjin Park, Minkee Park, Chan Hee Nam, Soon-Tae Hong, Myung Hwa Kim, Byung Cheol Park
    From the encyclopedia
    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

    Finasteride →

    Frontline, gold standard treatment for combatting androgenic alopecia

    Hair Transplant →

    Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.

    Studysummary Hair transplantation successfully treated hair loss in a patient with Trichorhinophalangeal syndrome. Our plain-language summary of this paper — not a Tressless recommendation.
    A 17-year-old male with Trichorhinophalangeal syndrome (TRPS) experienced progressive alopecia despite treatments with 5% minoxidil and 1 mg daily finasteride over 2 years. Gene analysis revealed down-regulation of the TRPS gene in balding scalp areas. Hair transplantation of 1,300 follicular units from the occipital to the frontal and mid-scalp areas resulted in successful hair growth over 3 years, with the patient expressing satisfaction and no complications. The study concluded that while conventional treatments for male pattern baldness were ineffective for TRPS-related alopecia, hair transplantation proved to be a viable cosmetic solution.
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