Ectopic Production of Hair Keratin Constitutes Rushton's Hyaline Bodies in Association with Hematogenous Deposits

April 2012 in “ Journal of Oral Pathology and Medicine ”

Kei Sakamoto, Rumana Khanom, Miwako Hamagaki, Akira Yamaguchi

hair keratin keratin 17 Rushton’s hyaline bodies odontogenic cysts hemoglobin alpha chain erythrocytic substances amyloidogenic proteins

TLDR Rushton's hyaline bodies form from hair keratin and blood substances.

This study investigated the origin of Rushton’s hyaline bodies (HBs) found in odontogenic cysts, analyzing 10 specimens from 400 cysts. The research revealed that HBs contained hair keratin and keratin 17, with hair keratin concentrated in HBs and keratin 17 observed near them. HBs also tested positive for hemoglobin alpha chain. The study concluded that HBs formed due to two independent events: the unusual production of hair keratin and hemorrhage providing erythrocytic substances. This reconciled the debate between the keratin and hematogenous theories, suggesting both are necessary for HB formation and proposing that HBs might be novel non-pathological amyloidogenic proteins.

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Research cited in this study

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research The Catalog of Human Hair Keratins

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research Expression of a truncated form of hHb1 hair keratin in human breast carcinomas

14 citations , December 1998 in “British Journal of Cancer”

Truncated hHb1 keratin may play a role in breast cancer cell transformation.

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