Hair Follicle Pigmentation
TLDR Hair color is determined by melanin produced and transferred in hair follicles.
The document discussed the complex process of hair follicle pigmentation, focusing on the interactions between melanocytes, keratinocytes, and dermal papilla fibroblasts. Follicular melanogenesis (FM) involved the production and transfer of melanin to keratinocytes, forming pigmented hair shafts, and was regulated by various enzymes, proteins, transporters, and receptors. FM was active during the anagen stage of the hair cycle and ceased during catagen and telogen stages. Melanocyte compartments in the upper hair follicle served as a reservoir for epidermal repigmentation and new hair bulb formation. Melanin synthesis and transfer depended on melanin precursors and signal transduction pathways, influenced by hormonal signals and various receptors and ligands. Melanin had bioactivities beyond determining hair color.
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