Hacat Keratinocytes Express Functional Receptors For Thyroid-Stimulating Hormone

May 2010 in “ Journal of Dermatological Science ”

David M. Pattwell, Katherine J. Lynaugh, Rachel Watson, Ralf Paus

thyroid-stimulating hormone TSH HaCaT keratinocytes human hair follicles epidermal keratinocytes dermal fibroblasts neuroendocrine signals hypothalamic–pituitary axis

Studysummary Human skin cells can respond to thyroid-stimulating hormone, affecting hair and skin health.

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research Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone

90 citations , December 2008 in “Journal of Investigative Dermatology”

Thyroid-stimulating hormone affects hair follicles but doesn't change hair growth or color.

research Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol

489 citations , June 2005 in “The FASEB Journal”

This study found that human scalp hair follicles can respond to corticotropin releasing hormone stimulation similarly to the classical HPA axis, including up-regulating cortisol production and activating neuroendocrine feedback loops.

research Expression of Hypothalamic-Pituitary-Thyroid Axis Related Genes in Human Skin

155 citations , December 2002 in “Journal of Investigative Dermatology”

This study found that thyroid-stimulating hormone receptors are functionally expressed in various skin cells, implying potential physiological and pathological roles in skin, especially in conditions like autoimmune diseases.