Hacat Keratinocytes Express Functional Receptors For Thyroid-Stimulating Hormone

    May 2010 in “ Journal of Dermatological Science ”
    David M. Pattwell, Katherine J. Lynaugh, Rachel Watson, Ralf Paus
    TLDR Human skin cells can respond to thyroid-stimulating hormone, affecting hair and skin health.
    The study demonstrated that HaCaT keratinocytes, a type of human skin cell, expressed functional receptors for thyroid-stimulating hormone (TSH). This finding supported the concept that human skin acted as a non-classical target for neuroendocrine signals, similar to the hypothalamic–pituitary axis. The research highlighted that TSH could induce changes in gene expression in human hair follicles, epidermal keratinocytes, and dermal fibroblasts, suggesting a broader role for TSH in skin physiology and potentially influencing conditions related to hair growth and skin health.
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