TLDR Hidradenitis suppurativa has had many names, but its naming is still not agreed upon.
The document traces the historical evolution of the terminology and understanding of Hidradenitis suppurativa (HS), a chronic inflammatory condition of the hair follicles and sweat glands. Initially described by Velpeau in 1833 as a tuberiform phlegmon, it underwent several name changes, reflecting evolving insights into its pathogenesis. Verneuil, in the mid-19th century, recognized it as a sweat gland disorder, coining the term 'hidradenitis suppurativa.' Subsequent terms like 'acnitis' and 'folliclis' were introduced but later rejected. Pillsbury's 'follicular occlusion triad' in 1956 and Plewig and Kligman's 'acne tetrad' in 1975 further refined its classification. Despite suggestions to rename it 'acne inversa' based on histopathological similarities, HS remains the accepted term, highlighting ongoing debates and the need for further research.
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April 2017 in “Journal of Investigative Dermatology” Dermal Wnt/β-catenin signaling is important for the proper size and development of hair follicles.
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January 2005 in “International review of cytology”
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August 2001 in “Experimental Dermatology” Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
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July 2001 in “Trends in Molecular Medicine” Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.