Dose-Dependent Valproate-Induced Alopecia in Patients with Mental Disorders
January 2015
in “
Indian Journal of Pharmacology/The Indian journal of pharmacology
”
New to Valproic acid? There is a guide in the encyclopedia. Read the guide → Studysummary This study reports that alopecia may develop in patients with chronic exposure to high plasma concentrations of valproate, but resolved after dose reduction or treatment discontinuation.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The document from 2015 reported three cases of alopecia (hair loss) in patients who were treated with sodium valproate for mental disorders. The alopecia appeared after long-term exposure to high plasma concentrations of valproate (approximately 100 µg/ml). However, the hair loss resolved in all cases after the dose was reduced or the treatment was discontinued. The study concluded that alopecia may develop in patients with chronic exposure to high plasma concentrations of valproate. Therefore, patients with high plasma concentrations of valproate should be closely monitored for side effects, particularly alopecia.
