Valproic Acid (Depakene): A New Anticonvulsant Agent

November 1978 in “ JAMA ”

J. R. Lewis

TLDR Valproic acid is an effective seizure medication with some temporary side effects.

Valproic acid was introduced as a new anticonvulsant agent, particularly effective for absence seizures, and showed improvement in tonic-clonic seizures, mixed absence with tonic-clonic seizures, and myoclonic epilepsy. It could be used alone or with other anticonvulsants, potentially allowing for reduced dosages of the latter. Some patients unresponsive to other treatments responded to valproic acid. Adverse reactions were reported in about 20% of patients, with gastrointestinal disturbances and drowsiness being the most common, especially when used with other anticonvulsants. Hair loss was a less frequent side effect. These adverse effects were generally temporary and did not necessitate stopping the medication.

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community Here is my hair regrowth plan

in Treatment 4 upvotes 5 years ago

The user's hair regrowth plan includes topical treatments (RU58841, azelaic acid, ketoconazole), oral supplements (Gia Herbs, castor oil), microneedling, PTD-DBM peptide with valproic acid, red light therapy, inversion table with scalp massage, and platelet-rich fibrin injections. Commenters suggest that finasteride and minoxidil are essential treatments for male pattern hair loss, which are missing from the plan.

community I’m starting PTD-DBM and valproic acid today - anyone with experience?

in Treatment 2 upvotes 4 years ago

The conversation is about using PTD-DBM and valproic acid for hair loss. The user is inquiring about the dosage of these treatments, noting that valproic acid is used at a 7.5% solution.

community Topical Valproic acid/sodium valproate — has anyone tried this?

in Question 2 upvotes 6 years ago

The conversation is about using valproic acid, an anti-seizure medication, as a topical treatment to promote hair growth. The original poster is seeking personal experiences from those who have tried this method.

community Topical VPA - Anyone experiences here?

in Question 2 upvotes 7 years ago

The conversation is about using topical valproic acid (VPA) for hair loss, focusing on its application method, usage frequency, and combination with other treatments like micro-needling. No specific experiences with VPA were shared.

community Ordered PTD-DBM from tailor made

in Product 5 upvotes 4 years ago

The conversation discusses hair loss treatments, including finasteride, microneedling, minoxidil, and PTD-DBM. The user has not noticed significant regrowth and is considering cost-effective options like valproic acid.

community Figuring out my own experimental protocol

in Treatment 10 upvotes 2 years ago

User tries dermapen for hair loss and plans to use non-mainstream topicals like c60, ghk-cu, and ptd-dbm with valproic acid. They also use a head massager and modified LLLT belt for additional treatment.