Polymorphism of Genes in Patients With New Coronavirus Infection COVID-19

The document reviewed genetic polymorphisms in COVID-19 patients, highlighting significant variability in infection and mortality rates across demographics. It suggested that gender differences in X-linked gene polymorphisms might explain disparities between men and women. The study emphasized the role of SNPs in genes like ACE2 and TMPRSS2 in determining susceptibility and disease severity, with certain SNPs linked to severe outcomes and ethnic specificity. Genetic variations in KLRC2del, HLA-E*0101, and IL-6 were identified as independent risk factors, with IL-6 polymorphisms affecting mortality rates and tocilizumab being effective in severe cases. The study involved 659 patients with severe pneumonia and 534 with mild or asymptomatic infections, underscoring the importance of genetic factors in disease progression and potential personalized treatments.