ACE1 rs1799752 Polymorphism Is Not Associated With Long-COVID Symptomatology In Previously Hospitalized COVID-19 Survivors

    December 2022 in “ Journal of Infection ”
    César Fernández‐de‐las‐Peñas, Lars Arendt‐Nielsen, Gema Díaz‐Gil, Antonio Gil-Crujera, Stella M. Gómez-Sánchez, Silvia Ambite‐Quesada, María Angustias Palomar-Gallego, Oscar J. Pellicer‐Valero, Rocco Giordano
    TLDR The ACE1 gene variant doesn't affect long-COVID symptoms.
    A study of 288 previously hospitalized COVID-19 survivors found no significant association between the ACE1 rs1799752 polymorphism and long-COVID symptoms, consistent with previous findings regarding ACE2 and TMPRSS2 polymorphisms. The research suggests that genetic variability might explain the lack of association and notes that COVID-19 severity does not necessarily correlate with long-COVID development. The study's limitations include its focus on hospitalized patients and the need for larger sample sizes to confirm the findings.
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