April 2018 in “Journal of Investigative Dermatology” This study found that the protein Fetuin A, when injected into fetal wounds that typically heal without scarring, caused scar formation and increased collagen production in fibroblasts in an animal model.
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December 2025 in “International Journal of Molecular Sciences” This study reported that atelocollagen enhances collagen synthesis and reduces oxidative stress in aged skin by increasing glycine uptake through GlyT1, resulting in improved skin elasticity and collagen density in aged mice, with effects superior to glycine alone.
September 2022 in “PubMed” This study found that decreased COL17α1 expression in aging mouse skin is associated with reduced proliferation of epidermal stem cells and may contribute to thinner epidermis and slower wound healing.
August 2026 in “Journal of Cosmetic Dermatology” This animal study found that transparent porcine-derived Type I atelocollagen increases skin thickness and regenerates elastic fibers in aged mice, suggesting its potential as a skin booster for rejuvenation.
April 2023 in “Journal of Investigative Dermatology” In this study, recombinant type III collagen was found to promote fibroblast proliferation and migration, suggesting potential anti-aging and repairing effects, although it was only effective in significantly inhibiting IL-6, not TNF-α, secretion.