Study on the Formulation and Characterization of a Photoprotective Cream Containing a Newly Synthesized Compound

September 2020 in “ Journal of Mind and Medical Sciences ”

Teodora Balaci, Emma Adriana Ozon, Daniela Luiza Baconi, Georgiana Nițulescu, Bruno Ștefan Velescu, Cristian Bălălău, Ioana Păunică, Ancuța Cătălina Fița

photoprotective cream organic sunscreen p-aminosalicylic acid 2,6-dichloroacetanilide metal oxides natural extracts nanostructured lipid carriers UV filter SPF sunscreen sunblock

Studysummary This study synthesized a new organic sunscreen with broad photoprotective properties and demonstrated it to be non-toxic. The resultant cream, containing nanostructured lipid carriers, showed suitable application qualities and achieved a satisfactory SPF value of 16.

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The study formulated a photoprotective cream with a new compound synthesized from p-aminosalicylic acid and 2,6-dichloroacetanilide, encapsulated in nanostructured lipid carriers to enhance efficacy and reduce toxicity. The cream included inorganic filters, natural products, and antioxidants, providing UVA and UVB protection, hydration, and anti-free radical benefits. Acute toxicity tests on 10 NMRI mice showed no significant adverse effects, confirming safety. The cream had stable physicochemical properties, a pH of 6.3, and maintained quality over 3 months. It demonstrated a satisfactory SPF of 16, good spreadability, and pseudoplastic flow behavior, effectively protecting skin from sunburn without irritation.

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