Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery
July 2009
in “International Journal of Pharmaceutics”
TLDR Niosomes improve minoxidil skin delivery for hair loss treatment.
This study explores the use of niosomes, a type of vesicular carrier, to improve the skin delivery of minoxidil, a drug used to treat hair loss. The niosomes were prepared using different surfactants, cholesterol, and drug amounts, and were characterized for entrapment efficiency, particle size, zeta potential, and stability. Skin permeation studies were performed using hairless mouse skin, and the results showed that the niosomal formulations had a higher retention of minoxidil inside the vesicles and enhanced the percentage of dose accumulated in the skin compared to commercial and control formulations. The study suggests that niosomal formulations could be a promising approach for the topical delivery of minoxidil in hair loss treatment.
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research Liposomes and niosomes as potential carriers for dermal delivery of minoxidil
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