TLDR The herbal hair cream could help treat male pattern baldness by blocking a baldness-related enzyme and might be worth further investigation.
The study aimed to develop a herbal hair cream to manage Androgenetic Alopecia, focusing on the inhibition of the 5 alpha reductase enzyme, which converts testosterone into dihydrotestosterone, a key factor in male pattern baldness. The cream contained 0.5% extracts of Hibiscus rosa sinensis flower, Eclipta alba whole plant, and Solanum nigrum plant berries in a 1:1:1 ratio. These extracts were found to contain 0.35% oleanolic acid, 4.65% β-sitosterol, and 31.18% linoleic acid. In-vitro results showed a good 5α-reductase inhibitory potential, with the IC50 value of the developed formulation being 85.254 ± 0.888 μg/ml, compared to 223.039 ± 1.367 ng/ml for finasteride, a synthetic medication. The study concluded that the herbal hair cream could benefit alopecia therapy by inhibiting the 5α-reductase enzyme and could be a potential option for further research into its antiandrogenic properties.View this study on ijlpr.com →
The herbal hair cream could help treat male pattern baldness by blocking a baldness-related enzyme and might be worth further investigation.
Both drugs lower DHT levels, with GI198745 being more effective.
Finasteride effectively inhibits 5α reductase, while plant extracts like Permixon and Bazoton don't show significant results.