Familial Hypotrichosis of the Scalp: Autosomal Dominant Inheritance in Four Generations

    January 1991 in “ Acta Dermato Venereologica ”
    Hans Ibsen, Ole Clemmensen, F Brandrup
    TLDR A family had a genetic condition causing hair loss on the scalp, passed down through four generations.
    The study described a Danish family spanning four generations affected by hypotrichosis of the scalp, characterized by a gradual and diffuse hair loss leading to almost total scalp alopecia by ages 14-21. The condition began between ages 6-17 and was not associated with other ectodermal defects. Out of 22 family members, 9 were affected, and the pattern of inheritance was consistent with autosomal dominant transmission. A scalp biopsy indicated non-scarring alopecia with features similar to androgenetic alopecia.
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