Factors Affecting the Development of Alopecia Areata in Children

April 2022 in “ Health care of Tajikistan ”

S. S. Bozorov

alopecia areata lipid peroxidation antioxidant protection microcirculation vitamin D deficiency

TLDR Managing alopecia areata in children needs a personalized approach considering genetic, immune, and environmental factors.

The article analyzed various studies on the causes and development of alopecia areata in children, highlighting the influence of genetic, immune, and environmental factors. It emphasized the role of disruptions in lipid peroxidation and antioxidant protection, which affect organ function, local blood flow, and skin parameters. The study also noted the impact of microcirculation issues and vitamin D deficiencies on the condition. The authors concluded that managing alopecia areata in children required a personalized approach, considering factors like local blood flow, skin function, related health issues, vitamin D levels, and antioxidant system disruptions.

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Research cited in this study

11 / 11 results

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A young child with alopecia areata and psoriasis improved with treatment, suggesting a link between the two conditions.

research Alopecia Areata and the Gut: The Link Opens Up for Novel Therapeutic Interventions

48 citations , May 2018 in “Expert Opinion on Therapeutic Targets”

Gut health may influence Alopecia Areata, suggesting new treatments.

research Prevalence of pediatric alopecia areata among 572,617 dermatology patients

28 citations , October 2017 in “Journal of the American Academy of Dermatology”

research Treatment of an Alopecia Areata Patient with Tofacitinib Results in Regrowth of Hair and Changes in Serum and Skin Biomarkers

70 citations , April 2016 in “Experimental Dermatology”

A patient with alopecia areata regrew hair after taking tofacitinib and showed changes in certain blood and skin markers.

research Epidemiology and Burden of Alopecia Areata: A Systematic Review

144 citations , July 2015 in “Clinical, Cosmetic and Investigational Dermatology”

Alopecia areata is a common autoimmune disease affecting about 2% of people, causing significant disability and often associated with mental health issues and other autoimmune conditions.

research Reduced Level of 25-Hydroxyvitamin D in Chronic/Relapsing Alopecia Areata

40 citations , April 2013 in “Dermato-endocrinology”

People with chronic Alopecia Areata often have lower vitamin D levels.

research Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata

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Alopecia areata is caused by immune system attacks on hair follicles, often triggered by viral infections.

research British Association of Dermatologists’ Guidelines for the Management of Alopecia Areata 2012

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Guidelines suggest various treatments for alopecia areata, but leaving it untreated is also an option as 80% cases may recover on their own.

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Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.

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