Exogenous IL-27 Prevents the Development of Alopecia Areata

    May 2024 in “ The Journal of Immunology
    Samuel Connell, Payton Kahl, Zhaowen Zhu, Maddison Lensing, Sydney B. Crotts, Xue‐Feng Bai, Ali Jabbari
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    Studysummary In a mouse model of alopecia areata, this study found that IL-27 overexpression using an adeno-associated virus protected against disease development, potentially by promoting immunosuppressive T cells and reducing CD8 T cell infiltration into hair follicles.
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