Interventional Evaluation of Monoammonium Glycyrrhizinate-Glycine/DL-Methionine Combination Tablets in Mild Alopecia Areata

January 2015 in “ Journal of clinical & experimental dermatology research ”

Yoshiaki Kubo, Toshitatsu Nogita, Ikuko Kimura, Mami Chiba, Kanako Sakakibara

monoammonium glycyrrhizinate glycine DL-methionine carpronium chloride alopecia areata combination therapy monotherapy allergic factors MG CC AA

From the encyclopedia

Glycine →

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Studysummary This study suggests that combining monoammonium glycyrrhizinate/glycine/DL-methionine tablets with 5% carpronium chloride may reduce alopecia areata area more effectively than carpronium chloride alone, particularly in patients with allergic factors.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study evaluated the efficacy and safety of monoammonium glycyrrhizinate/glycine/DL-methionine (MG) tablets combined with 5% carpronium chloride (CC) in treating mild alopecia areata (AA) in 31 patients. Results showed no significant differences in efficacy between the combination therapy and CC monotherapy, but both treatments significantly reduced the AA area at 8 and 12 weeks. In patients with allergic factors, the combination therapy led to significant decreases in AA areas at 8 and 12 weeks (p<0.05). No serious adverse events were reported, suggesting that MG and CC combination therapy may offer better therapeutic effects than CC alone, particularly in patients with allergic factors.

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Research cited in this study

8 / 8 results

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research Diffuse Alopecia Areata Is Associated With Intense Inflammatory Infiltration and CD8+ T Cells in Hair Loss Regions and an Increase in Serum IgE Level

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This study identified four genetic loci on chromosomes 6, 10, 16, and 18 that may contribute to susceptibility for alopecia areata and suggested shared genetic factors with psoriasis.

research Effects of Carpronium Chloride on the Microvascular Blood Flow in Rat Mesentery Using Intravital Videomicroscopy

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This study found that topical application of carpronium chloride led to arteriolar vasodilation and increased blood flow in rat mesenteric arterioles, without affecting systemic blood pressure.