Multiple Eruptive Dermatofibromas in a Patient With Systemic Lupus Erythematosus Treated With Methylprednisolone

A 37-year-old female with systemic lupus erythematosus (SLE) developed multiple eruptive dermatofibromas (MEDFs) after being treated with methylprednisolone and hydroxychloroquine sulphate. MEDFs are rare, accounting for less than 0.3% of all dermatofibromas, and are characterized by the appearance of multiple lesions within a short period. The patient had no history of trauma or insect bites, and the lesions resolved spontaneously without treatment. MEDFs are often associated with immune dysregulation, and in this case, the use of immunosuppressive drugs like steroids may have contributed to their development. The study highlighted the importance of recognizing the potential for MEDFs in patients with SLE undergoing such treatments.