TLDR Epidermolysis bullosa in calves was not caused by mutations in the keratin genes bKRT5 and bKRT14.
Epidermolysis bullosa (EB) was identified in eight calves across four farms in the UK, involving Simmental and Holstein-Friesian breeds. The condition was characterized by multifocal erosion and ulceration in various areas, including the mouth and limbs, along with alopecia and crusting. Histopathological analysis revealed separation of the epidermis from the dermis, forming clefts with fluid and blood cells, affecting both follicular and interfollicular skin areas. Ultrastructural examination showed vacuolar changes in basal keratinocytes. Genetic screening ruled out mutations in the keratin genes bKRT5 and bKRT14 as the cause of EB in these cases.
21 citations
,
November 2009 in “Dermatologic Clinics” The document suggests that certain protein deficiencies and scalp blistering in Epidermolysis Bullosa may cause hair loss.
85 citations
,
July 2012 in “Cold Spring Harbor perspectives in biology” The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.
The document explains different types of skin lesions and their characteristics, causes, and related conditions.
January 2018 in “Stem cell biology and regenerative medicine” The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.
8 citations
,
May 2021 in “Bioengineering & translational medicine” Hair growth environment recreated with challenges; stem cells make successful skin organoids.
2 citations
,
March 2020 in “International Journal of Molecular Sciences” Topical treatments can deliver active molecules to skin stem cells, potentially helping treat skin and hair disorders, including skin cancers and hair loss.
