Investigation of the Comprehensive Treatment’s Clinical Efficacy of Various Types of Alopecia Using Proteoglycan Replacement Therapy

April 2023 in “ Russian Journal of Clinical Dermatology and Venereology ”

Aida Gadzhigoroeva, Yu. Yu. Romanova, В В Вавилов, Yu.A. Markova

proteoglycan replacement therapy androgenetic alopecia telogen effluvium phototrichogram AGA TE

TLDR Proteoglycan replacement therapy improved hair conditions in most patients with alopecia.

The study investigated the clinical efficacy of proteoglycan replacement therapy in treating androgenetic alopecia (AGA) and telogen effluvium (TE) in 42 patients (35 women and 7 men). After a 4-month treatment, 90.5% of patients showed positive improvements, with 87.5% of AGA patients and 100% of TE patients experiencing significant progress. Follow-up phototrichogram analysis in 18 patients revealed improvements in all hair parameters for TE patients and all but average hair diameter for AGA patients, indicating the therapy's potential effectiveness in managing these types of alopecia.

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Investigation of the Comprehensive Treatment’s Clinical Efficacy of Various Types of Alopecia Using Proteoglycan Replacement Therapy

Research cited in this study

research Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms Behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin with Marilex in Pattern Hair Loss and Telogen Effluvium

research Isolation and Quantification of Glycosaminoglycans from Human Hair Shaft

research The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells

research A Newly Discovered Linkage Between Proteoglycans and Hair Biology: Decorin Acts as an Anagen Inducer

research Hair Cycle-Specific Expression of Versican in Human Hair Follicles

research Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling

research Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

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