Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

June 1987 in “ Archives of Dermatological Research ”

Kensei Katsuoka, Hanna Schell, Birgit Wessel, Otto P. Hornstein

epidermal growth factor fibroblast growth factor minoxidil hydrocortisone hair bulb papilla cells root sheath fibroblasts dermal papilla EGF FGF Rogaine

TLDR EGF and FGF boost hair cell growth, hydrocortisone slows it, and minoxidil doesn't affect it.

This study examined the effects of epidermal growth factor, fibroblast growth factor, minoxidil, and hydrocortisone on the growth of human hair bulb papilla cells and root sheath fibroblasts cultured in vitro. The results showed that EGF and FGF increased proliferation of both cell types, while hydrocortisone slowed proliferation, and minoxidil had no effect. The study suggests that the dermal papilla can be considered a target tissue for agents influencing maintenance of hair growth.

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