The Location and Proliferation of Human Hair Follicle Stem Cells

January 2006 in “ Chinese Journal of Dermatology ”

Lei Zhang

hair follicle stem cells bulge area outer root sheath hair bulb follicle epithelium mesenchymal cells dermal papilla cells keratinocytes apoptotic cells

TLDR Mesenchymal cells are essential for hair follicle stem cell growth.

The study investigated the location and proliferation of human hair follicle stem cells, identifying two distinct stem cell reservoirs in the hair follicles: one in the bulge area and another in the outer root sheath above the hair bulb. The research found that stem cell proliferation occurred only when the follicle epithelium was co-cultured with mesenchymal cells, specifically dermal papilla cells. The study concluded that mesenchymes are essential for stem cell proliferation, and the resulting colonies contained juvenile cells, mature keratinocytes, and apoptotic cells, indicating different stages of stem cell development.

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