Effectiveness of Combined Oral Contraceptives in Women with Polycystic Ovary Syndrome

The study aimed to compare the effectiveness of combined oral contraceptives with drospirenone and finasteride in women with polycystic ovary syndrome (PCOS) without metabolic abnormalities. It found that finasteride positively affected the ovarian follicular apparatus and more effectively reduced the luteinizing hormone to follicle-stimulating hormone ratio compared to drospirenone. However, drospirenone was more effective in reducing ovarian volume and the free androgen index. Notably, one patient became pregnant after finasteride treatment, while eight pregnancies occurred following the use of drospirenone due to the "rebound effect." Both treatments demonstrated significant therapeutic effects in managing PCOS symptoms.