Effect of Finasteride in Idiopathic Hirsutism

November 1998 in “ Journal of Endocrinological Investigation ”

Emanuela Faloia, Filipponi S, Valentina Mancini, S. Di Marco, Franco Mantero

finasteride idiopathic hirsutism 5α-reductase hirsutism Propecia

TLDR Finasteride significantly reduces hair growth in women with idiopathic hirsutism.

The study evaluated the effectiveness of finasteride in treating idiopathic hirsutism in women. The treatment was well-tolerated and resulted in a significant reduction in hair growth. Finasteride may be an effective treatment option for idiopathic hirsutism. The study found that finasteride was effective in reducing hirsutism in 14 female patients with no reported side effects. The improvement was observed after 6 months of therapy, suggesting that increased 5α-reductase activity may play a role in excessive hair growth in idiopathic hirsutism. The study suggests that adequate contraception is necessary when using finasteride.

View this study on link.springer.com →

Discuss this study in the Community →

Cited in this study

17 / 17 results

research Outcome of Long-Term Treatment with the 5α-Reductase Inhibitor Finasteride in Idiopathic Hirsutism: Clinical and Hormonal Effects During a 1-Year Course of Therapy and 1-Year Follow-Up

75 citations , November 1996 in “Fertility and Sterility”

Finasteride effectively reduces hair growth in women with idiopathic hirsutism, but requires careful contraception during treatment.

research Finasteride in the Treatment of Hirsutism: New Therapeutic Perspectives

50 citations , July 1996 in “Fertility and Sterility”

Finasteride effectively treats hirsutism in women, but more research needed for long-term results.

research Clinical and endocrine effects of finasteride, a 5α-reductase inhibitor, in women with idiopathic hirsutism

70 citations , August 1995 in “Fertility and Sterility”

Finasteride reduces hairiness and androgen levels in women with unexplained excessive hair growth.

research A prospective randomized trial comparing finasteride to spironolactone in the treatment of hirsute women.

52 citations , January 1995 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride and spironolactone both reduce hirsutism, but finasteride lowers androgen levels more.

research Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism.

33 citations , October 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces hair growth and is safe for women with excessive hair.

research Effects of finasteride, a 5 alpha-reductase inhibitor, on circulating androgens and gonadotropin secretion in hirsute women.

22 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces dihydrotestosterone, increases testosterone, and may treat hirsutism in women.

research The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness.

59 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

research Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial

165 citations , February 1994 in “Fertility and Sterility”

Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.

research Hepatotoxicity Complicating Flutamide Treatment of Hirsutism

43 citations , December 1993 in “Annals of internal medicine”

Flutamide, a medication used for excessive hair growth, can cause severe liver damage in women.

research Finasteride

86 citations , July 1993 in “Drugs”

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

research Azasteroids as inhibitors of testosterone 5α-reductase in mammalian skin

34 citations , February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

research Structure of human type II 5 alpha-reductase gene.

124 citations , September 1992 in “Endocrinology”

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

research Comparison of Sequential Cyproterone Acetate/Estrogen Versus Spironolactone/Oral Contraceptive in the Treatment of Hirsutism

68 citations , May 1991 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Both cyproterone acetate and spironolactone effectively reduce hair growth in women with hirsutism.

1 / 1 results

research PLASMA C19 STEROID SULPHATE LEVELS AND INDICES OF ANDROGEN BIOAVAILABILITY IN FEMALE PATTERN ANDROGENIC ALOPECIA

32 citations , January 1990 in “Clinical Endocrinology”

Women with female pattern hair loss have higher levels of certain androgens, suggesting increased androgen exposure to hair follicles.