Novel ECM Patch Combines Poly(Vinyl Alcohol), Human Fibroblast-Derived Matrix, and Mesenchymal Stem Cells for Advanced Wound Healing

June 2020 in “ ACS Biomaterials Science & Engineering ”

Sang Su Ha, Eui Sun Song, Ping Du, Muhammad Suhaeri, Jong-Ho Lee, Kwideok Park

extracellular matrix human fibroblast-derived matrix poly(vinyl alcohol) mesenchymal stem cells cytocompatibility cell migration wound closure epidermis thickness hair follicle regeneration collagen deposition neovascularization ECM hFDM PVA hMSCs

TLDR The new ECM patch greatly improves wound healing and tissue regeneration.

The study developed a novel ECM patch combining human fibroblast-derived matrix and poly(vinyl alcohol) hydrogel, which was compatible with human mesenchymal stem cells. This patch significantly improved cell migration and accelerated wound healing in a mouse model, showing advanced tissue regeneration, including nearly normal epidermis thickness, hair follicle regeneration, mature collagen deposition, and neovascularization. The study concluded that the engineered ECM patch had strong regenerative potential for advanced wound healing.

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