Association of Early-Onset Androgenetic Alopecia and Metabolic Syndrome in Thai Men: A Case-Control Study

August 2013 in “ PubMed ”

Nopparat Pengsalae, Chuchai Tanglertsampan, Thanaphat Phichawong, Saridpong Lee

androgenetic alopecia metabolic syndrome early-onset androgenetic alopecia cardiovascular diseases AGA

TLDR Men with early-onset hair loss have a higher risk of metabolic syndrome.

The study investigated the association between early-onset androgenetic alopecia (AGA) and metabolic syndrome in Thai men, involving 80 male subjects, 40 with early-onset AGA and 40 controls. It found that men with early-onset AGA had a 3.48-fold higher risk of developing metabolic syndrome compared to the control group. However, there was no relationship between the severity of AGA and metabolic syndrome. The study suggested that early detection of metabolic syndrome in this population could help prevent cardiovascular diseases.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

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Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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The user has been using a combination of oral finasteride, oral dutasteride, topical and oral minoxidil, microneedling, and keto shampoo for hair loss, experiencing significant shedding recently. Suggestions include simplifying the regimen by dropping finasteride and topical minoxidil, and possibly adding RU58841, while others advise maintaining the current approach for consistent results.

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Oral minoxidil is effective for hair loss but can cause cardiovascular side effects, such as pericardial effusion, especially in those with genetic predispositions. Starting with low doses and monitoring cardiovascular health are advised to reduce risks.

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Dutasteride and finasteride may temporarily affect semen quality but are unlikely to cause permanent infertility. The Kim et al. study is criticized for poor methodology, and many prefer hair retention over potential fertility concerns, using treatments like dutasteride, finasteride, and minoxidil.

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