Effect of a Combination of Dutasteride and Parenteral Testosterone Undecanoate on Testosterone Deficiency Symptoms and Prostate in Patients with Testosterone Deficiency and Benign Prostatic Hyperplasia

January 2020 in “ Journal of Men s Health ”

Sun Park, Seok Cho, Jae Hwan Kim, Jeong Kyun Yeo, Min Park

dutasteride testosterone undecanoate testosterone deficiency benign prostatic hyperplasia prostate volume Avodart Nebido BPH TD

Studysummary In this study of BPH patients with testosterone deficiency, the combination of TU and dutasteride reduced prostate volume and improved testosterone-related symptoms but was less effective for sexual function compared to TU alone, indicating caution in using dutasteride for those with sexual dysfunction concerns.

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The study examined the effects of combining testosterone undecanoate (TU) and dutasteride in 130 patients with testosterone deficiency (TD) and benign prostatic hyperplasia (BPH). It found that both treatments improved testosterone levels and alleviated TD symptoms, but the combination treatment significantly reduced prostate volume more than TU alone. However, the combination was less effective in improving sexual function symptoms. The study concluded that while the combination therapy effectively reduced prostate volume, caution was advised when using dutasteride in patients primarily concerned with sexual dysfunction.

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