TLDR Dupilumab can help hair regrowth but may also trigger alopecia areata.
The commentary discusses the complex pathogenesis of alopecia areata (AA), highlighting the role of immune privilege loss, autoimmune-mediated destruction of hair follicles, and abnormal inflammatory pathway regulation. Despite recent advances in treatment options like platelet-rich plasma, JAK–STAT inhibitors, and PDE4 inhibitors, the efficacy remains limited. The article presents a case of AA onset following dupilumab treatment, emphasizing the need to understand the chronological relationship between AA onset and dupilumab use. The study underscores the potential dual effects of dupilumab in treating AA. No conflicts of interest were reported, and no new data were generated.
11 citations,
January 2019 in “Acta Dermato Venereologica” Omalizumab may cause hair loss.
148 citations,
December 2018 in “Journal of autoimmunity” Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.
191 citations,
May 2018 in “British journal of dermatology/British journal of dermatology, Supplement” Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.
290 citations,
December 2017 in “Journal of The American Academy of Dermatology” Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.
January 2015 in “Journal of clinical & experimental dermatology research” A protein combining parathyroid hormone and collagen helped hair regrow in mice with a hair loss condition.
October 2023 in “Benha Journal of Applied Sciences” Methotrexate and vitamin D3 are potentially more effective and safer than triamcinolone for treating localized alopecia areata.
191 citations,
May 2018 in “British journal of dermatology/British journal of dermatology, Supplement” Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.
4 citations,
September 2019 in “Biomedical Papers/Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic” CD2 might be a new treatment target for patchy alopecia areata.
