Dual Inhibitors of Urease and Carbonic Anhydrase-II from Iris Species
July 2019
in “
Pure and Applied Chemistry
”
TLDR Some natural compounds from Iris plants can block enzymes related to certain disorders, with a few affecting both targeted enzymes.
The study isolated 27 compounds from Iris loczyi and Iris unguicularis and tested them for inhibitory effects on urease and carbonic anhydrase-II (CA-II) enzymes. Using NMR, IR, and mass spectroscopy for characterization, the study found that some compounds significantly inhibited CA-II, with compound 12 having the lowest IC50 value of 17.60 ± 0.08 µM against urease, and compound 3 being the most active against CA-II with an IC50 of 66.27 ± 0.89 µM. Six compounds were identified as dual inhibitors of both enzymes. Molecular docking studies using Autodock Vina and i-GEMDOCK software confirmed the potential interactions of the most active compounds with the enzymes, suggesting their therapeutic potential for disorders associated with urease and carbonic anhydrase. The study concluded that the natural inhibitors have more selectivity towards urease than CA-II and could be lead molecules for further research.
