Drug-Induced Liver Failure Following Topical Minoxidil: A Case Report

    January 2025 in “ Case Reports in Gastrointestinal Medicine ”
    Katrin Premke, Matthias Kästner, Carlos Fritzsche … Micha Loebermann
    Studysummary This case report presented by the authors provides the first evidence of severe liver failure associated with the use of topical minoxidil, emphasizing the potential for hepatotoxicity even from drugs with minimal systemic absorption.
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    Research cited in this study 12

    1. The Role of Minoxidil in the Treatment of Alopecia Areata: A Systematic Review and Meta-Analysis Journal of Clinical Medicine · 2024
    2. Hair Follicle Sulfotransferase Activity and Effectiveness of Oral Minoxidil in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2024
    3. Side Effects of Low-Dose Oral Minoxidil for Treating Alopecia Journal of The American Academy of Dermatology · 2021
    4. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    5. Minoxidil for Patchy Alopecia Areata: Systematic Review and Meta-Analysis Journal of The European Academy of Dermatology and Venereology · 2019
    6. Minoxidil Use in Dermatology, Side Effects, and Recent Patents Recent Patents on Inflammation & Allergy Drug Discovery · 2012
    7. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    8. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    9. Double-Blind, Placebo-Controlled Evaluation of Topical Minoxidil in Extensive Alopecia Areata Journal of The American Academy of Dermatology · 1987
    10. Topical Minoxidil for Hair Growth in Alopecia Areata and Androgenetica Drugs · 1987
    11. Percutaneous Absorption of Minoxidil in Humans Archives of Dermatology · 1985
    12. Pharmacology and Pharmacokinetics of Minoxidil Journal of Cardiovascular Pharmacology · 1980