Differential expression analysis of balding and nonbalding dermal papilla microRNAs in male pattern baldness with a microRNA amplification profiling method
March 2012
in “British Journal of Dermatology”
TLDR Certain microRNAs are more common in balding areas and might be involved in male pattern baldness.
The study investigated the role of microRNAs in male pattern baldness by analyzing their expression in the dermal papillae of eight individuals with the condition. The researchers found that four microRNAs (miR-221, miR-125b, miR-106a, and miR-410) were significantly upregulated in balding papilla cells compared to nonbalding cells. These findings suggest that these microRNAs may contribute to the development of male pattern baldness and could be targets for new gene therapy treatments. Although one microRNA (miR-340) was downregulated, the change was not statistically significant. The research indicates a need for further high-throughput studies to better understand the roles of microRNAs in this condition.
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